Cross-kingdom patterns of alternative splicing and splice recognition
نویسندگان
چکیده
منابع مشابه
thE splicE AnD splicing AltErnAtivE prOcEssEs
RNA splicing is an essential, precisely regulated process that occurs after gene transcription and before mRNA translation, in which introns may be removed and exons, retained. Variability in splicing patterns is a major source of protein diversity from the genome and function to generate a tremendously diverse proteome from a relatively small number of genes. Changes in splice site choice can ...
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Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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Alternative splicing (AS) constitutes a major mechanism creating protein diversity in humans. Previous bioinformatics studies based on expressed sequence tag and mRNA data have identified many AS events that are conserved between humans and mice. Of these events, approximately 25% are related to alternative choices of 3' and 5' splice sites. Surprisingly, half of all these events involve 3' spl...
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Alternative splicing (AS) constitutes a major mechanism creating protein diversity in humans. Previous bioinformatics studies based on expressed sequence tag and mRNA data have identified many AS events that are conserved between humans and mice. Of these events, 25% are related to alternative choices of 30 and 50 splice sites. Surprisingly, half of all these events involve 30 splice sites that...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2008
ISSN: 1465-6906
DOI: 10.1186/gb-2008-9-3-r50